Genotoxic and antigenotoxic potential of encapsulated Enhalus acoroides (L. f.) Royle leaves extract against nickel nitrate

Several environmental pollutants can cause damage to chromosomes, one of which is the heavy metal NiNO3. Some plant extracts have antigenotoxic properties that result in a decrease chromosomal damage. Member flowering plants need be tested seagrass. One seagrass species Enhalus acoroides was found contain phytochemical compounds. This study aimed analyse genotoxic effect and potential encapsulated E. leaf extract as against nickel nitrate The extraction conducted using mixture chloroform ethanol, crude maltodextrin tween 80. Chromosomal aberrations were evaluated squash technique Allium cepa var. aggregatum root tips. Triphenyltetrazolium chloride Evans Blue staining used observe mitochondrial apoptotic activities. results showed at higher concentrations (250 ppm 500 ppm), decreased mitotic indices; however, no chromosome aberration observed. NiNO3 itself induced observed by low index high percentage aberration. modulation adding concentration (100 ppm) increased compared treatment with Ni alone, but did not reduce Simultaneous treatment, significantly reduced nuclear fragmentation lesion. repair several types cannot minimise